Comments on the relation among GAD-65, IA-2 antibodies and body adiposity
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چکیده
منابع مشابه
The Presence of GAD and IA-2 Antibodies in Youth With a Type 2 Diabetes Phenotype
OBJECTIVE To determine the frequency of islet cell autoimmunity in youth clinically diagnosed with type 2 diabetes and describe associated clinical and laboratory findings. RESEARCH DESIGN AND METHODS Children (10-17 years) diagnosed with type 2 diabetes were screened for participation in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Measurements included G...
متن کاملAge-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults.
Glutamic acid decarboxylase (GAD) and tyrosine phosphatase IA-2 antibody levels were measured in 375 healthy children and adults and in 187 children with newly diagnosed type 1 diabetes mellitus (DM). GAD antibody levels were determined by radioimmunoassay, and IA-2 antibody levels by immunoprecipitation. Healthy children had higher GAD antibody levels than adults (p < 0.001). The 98th percenti...
متن کاملZinc Transporter 8 Antibodies Complement GAD and IA-2 Antibodies in the Identification and Characterization of Adult-Onset Autoimmune Diabetes
OBJECTIVE Zinc transporter 8 (ZnT8) is an islet beta-cell secretory granule membrane protein recently identified as an autoantibody antigen in type 1 diabetes. The aim of this study was to determine the prevalence and role of antibodies to ZnT8 (ZnT8As) in adult-onset diabetes. RESEARCH DESIGN AND METHODS ZnT8As were measured by a radioimmunoprecipitation assay using recombinant ZnT8 COOH-ter...
متن کاملGAD - 65 and IA - 2 Autoantibodies in Relation to HLA Class II DR and DQ 3 Alleles and Haplotypes in Type 1 Diabetes Mellitus
26 Background. The frequency of autoantibodies against glutamic acid decarboxylase-65 27 (GAD65), and ICA512/IA2 (IA2) are a function of the specific human leukocyte antigen 28 (HLA) in type 1 diabetes mellitus (T1D). We investigated the association of HLA class II 29 (DR, DQ) alleles and haplotypes with the presence of GAD and IA-2 autoantibodies in T1D. 30 Methods. Autoantibodies were tested ...
متن کاملthe effect of lexical inferencing and concept mapping on the vocabulary retention among iranian intermediate efl learners
this study was an attempt to investigate and compare the effect of lexical inferencing and concept mapping on developing vocabulary retention of iranian language learners. sixty homogeneous students from different intact classes who were being taught as intermediate learners in sokhan english institute participated in this study. they were in different classes. a teacher made test as a pre-test...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2000
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250050020